The new entrepreneurial initiatives, appear on the market with a plurality of business and organizational models. These models, although successful in the short term, are likely to lose competitiveness in the long time. Only a model of knowledge management and organizational learning could be able to promote a cross-organizational value. This article aims to answer to the following questions: which models are able to support a University to fully realize its third mission? How innovative ideas, through researches, can become successful business? To address these questions, the article presents a growth model among Research-Innovation-Enterprise based on co-partnership of three categories of players: Pre-incubators of innovative ideas; Spin-Offs and Spin-Outs; Public-Private Laboratories. The methodological approach is based on an empirical analysis focused on the study of the territory and a theoretical analysis based on the interaction of three approaches: Process Approach; Product Approach; Rainforest Approach. This paper introduces Innovars Association as a Model of Innovation that embraces both the Responsible Research and Innovation (RRI) process and put in action the Targeted Open Innovation main rules.
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